Ethanol hydrochloride → HCID 22906480, compound

HRID 1779520Notes

Reaction equation

HRID 1779520 reaction equation
[CH2:1]([CH:3]([O:6][C:7]1[CH:16]=[C:15]2[C:10]([C:11](=[O:41])[CH:12]=[C:13]([S:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25](=[O:40])[C:26]4[CH:31]=[CH:30][C:29]([CH2:32][N:33]5[CH2:38][CH2:37][N:36]([CH3:39])[CH2:35][CH2:34]5)=[CH:28][CH:27]=4)=[CH:20][CH:19]=3)[O:14]2)=[C:9]([OH:42])[C:8]=1[O:43][CH3:44])[CH2:4][CH3:5])[CH3:2].[ClH:45].C(O)C>CCOCC>[ClH:45].[ClH:45].[CH2:1]([CH:3]([O:6][C:7]1[CH:16]=[C:15]2[C:10]([C:11](=[O:41])[CH:12]=[C:13]([S:17][C:18]3[CH:19]=[CH:20][C:21]([O:24][C:25](=[O:40])[C:26]4[CH:31]=[CH:30][C:29]([CH2:32][N:33]5[CH2:38][CH2:37][N:36]([CH3:39])[CH2:35][CH2:34]5)=[CH:28][CH:27]=4)=[CH:22][CH:23]=3)[O:14]2)=[C:9]([OH:42])[C:8]=1[O:43][CH3:44])[CH2:4][CH3:5])[CH3:2]

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 22906481HCID 22906481, compound

Product 1

HCID 22906480HCID 22906480, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

2.30 g of 7-(1-ethylpropoxy)-5-hydroxy-2-{4-[4-(4-methylpiperazinomethyl)benzoyloxy]phenylthio}-6-methoxychromone was dissolved in 30 ml ether, 20% hydrochloric acid-ethanol was added, and the solution was stirred over 20 min., under cooling on ice. The resulting crystals were collected by filtration and dried, whereby 2.35 g of 7-(1-ethylpropoxy)-5-hydroxy-2-{4-[4-(4-methylpiperazinomethyl)benzoyloxy]phenylthio}-6-methoxychromone dihydrochloride with the following physicochemical properties was obtained.

Workup

  1. temperatureunder cooling on ice
  2. filtrationThe resulting crystals were collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-4d7f4bb01ada4ba788cef864acc83359
Source dataset
uspto-grants-1997_05
Patent number
US05627204

Reaction notes

Loading…