HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 131719696, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Oxalic Acid | HCID 971 | — |
| Reactant | 2,3,4,5-Tetrahydro-1H-benzo(d)azepine | HCID 1400243 | — |
| Reactant | (2s)-Glycidyl indol-4-yl ether | HCID 10943254 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 131719696 | HCID 131719696 | — |
Reaction Steps
The title compound was prepared in similar fashion from (S)-(+)-4-(oxiranylmethoxy)-1H-indole and 2,3,4,5-tetrahydro-1H-3-benzazepine. The resulting free base was dissolved in ethyl acetate, and precipitated with one equivalent of oxalic acid in ethyl acetate in 73% overall yield. FDMS m/e=336 (M+ of free base). α[D]589 =-14.17 (c=0.61, methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05627196 |
| Source dataset | uspto-grants-1997_05 |
| ORD ID | ord-d1dcc27ddb6446f8a63a2f6d2ec08b4d |
| Source note | uspto-grants-1997_05 |