(2s)-Glycidyl indol-4-yl ether → HCID 56985622, compound

Participants

Reaction Steps

The title compound was prepared in a fashion similar to that described in Example 193 from 6-chloro-5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (0.80 g, 3.0 mmol) and (S)-(+)-4-(oxiranylmethoxy)-1H-indole (0.60 g, 3.2 mmol). The product was isolated as a yellow foam. Yield 260 mg (19%). mp 115°-120° C. FDMS m/e=452 (M+ of free base). α[D]589 =+6.62 (c=1.03, dimethylsulfoxide).

Provenance & Evidence