Butylamine → HCID 131720006, compound

Participants

Reaction Steps

5(S)-Azido-4(S),8(R,S)-dihydroxy-2(S),7(S)-diisopropyl-8-[4-methoxy-3-(2-methoxy-methoxyethyl)-phenyl]-octanoic acid (N-butyl)-amide A solution of 400 mg of 3(S)-isopropyl-4(S)-{1(S)-azido-4(R,S)-hydroxy-3(S)-isopropyl -4-[4-methoxy-3-(2-methoxymethoxyethyl)-phenyl]-butyl}-tetrahydrofuran-2-one (Example 81d) and 3.8 ml of n-butylamine is stirred for 16 hours at 50° C. and then concentrated by evaporation. Purification of the residue by FC (50 g of silica gel, hexane/ethyl acetate=1:1) yields the title compound: Rf (hexane/ethyl acetate=1:1)=0.44; HPLC Rt =16.13 and 17.03 minutes (diastereoisomeric mixture).

Provenance & Evidence