Dichloromethane → 4-{2-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamino]-thiazol-5-yl}-phenol

HRID 177988Notes

Reaction equation

HRID 177988 reaction equation
[B:1]([Br:2])([Br:3])[Br:4].[CH3:5][O:6][c:7]1[cH:8][cH:9][c:10](-[c:13]2[cH:14][n:15][c:16]([NH:18][c:19]3[cH:20][cH:21][c:22]([O:25][CH2:26][CH2:27][N:28]4[CH2:29][CH2:30][CH2:31][CH2:32]4)[cH:23][cH:24]3)[s:17]2)[cH:11][cH:12]1.[Cl:33][CH2:34][Cl:35]>>[OH:6][c:7]1[cH:8][cH:9][c:10](-[c:13]2[cH:14][n:15][c:16]([NH:18][c:19]3[cH:20][cH:21][c:22]([O:25][CH2:26][CH2:27][N:28]4[CH2:29][CH2:30][CH2:31][CH2:32]4)[cH:23][cH:24]3)[s:17]2)[cH:11][cH:12]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 25134Boron tribromideHCID 11188635[5-(4-Methoxy-phenyl)-thiazol-2-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine

Product 1

HCID 111882064-{2-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamino]-thiazol-5-yl}-phenol

Sources & evidence

ORD record
ord-6feb6dbaa5a24c86ac08717ea9e7b63f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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