反应详情

To an ice cooled mixture of 19.98 g (16.6 mmol) of benzamidine in 80 mL of acetone, was added dropwise over two hours, a solution of 16.35g (16.6 mmol) 2-methyl-2-pentenal and 0.055 g 1,4-hydroquinone, in acetone. The mixture was left to stir cold and warm to room temperature over 20 hours. The product was isolated by vacuum filtration and was washed with a minimal amount of acetone. 15.6 g (44%) of 6-ethyl-5-methyl-4-hydroxy-2-phenyl-3,4,5,6-tetrahydropyrimidine was collected, as a white solid.

1. additionwas added dropwise over two hours
2. waitThe mixture was left
3. customThe product was isolated by vacuum filtration
4. washwas washed with a minimal amount of acetone
5. custom15.6 g (44%) of 6-ethyl-5-methyl-4-hydroxy-2-phenyl-3,4,5,6-tetrahydropyrimidine was collected, as a white solid