Sodium Azide → HCID 86750806, compound

Participants

Reaction Steps

1-Bromo-4-[(2R,5S)-3,6-dimethoxy-2-isopropyl-2,5-dihydro-5-pyrazinyl]-butane (3.81 g, 11.95 mmol) were dissolved in 40 ml DMF and 3.25 g NaN3 (50 mmol) and 0.1 g NBu4I were added. The solution was kept between 70° and 80° C. overnight and diluted with 50 ml water. After extraction with chloroform the organic layers were collected and dried (MgSO4). The residue was purified by flash chromatography (hexane/ethyl acetate 9/1).

Provenance & Evidence