Water → HCID 19049246, compound

Participants

Reaction Conditions

Reaction Steps

The 36 g of compound obtained in Example 9 are added to 200 ml of a mixture of water and acetic acid (1/1) and the whole is heated at reflux until the mixture becomes homogeneous, after which refluxing is maintained for a further 15 minutes. The disappearance of the acetonide is verified by thin-layer chromatography, then the mixture is cooled to 0° C., and the precipitate formed is filtered and then dried, yielding 30 g of the expected compound of 98% purity. Recrystallisation of that compound from a mixture of isopropanol and water yields the pure product, m.p.: 215°-218° C.

Provenance & Evidence