Dimethylamine → HCID 19049358, compound

Participants

Reaction Steps

A solution of 2-(2-bromoacetamido)-1-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-3,3-diphenylpropane (0.36 g, prepared by an analogous procedure to that described in Example 60, from bromoacetyl chloride) in tetrahydrofuran (20 ml) and dimethylamine (1 ml) was stirred at 0° C. for 1 hour, The solution was poured onto ethyl acetate and the solution washed with water, saturated brine and dried (MgSO4). After removal of the solvent in vacuo the residue was chromatographed on silica gel, followed by oxalate salt formation to give the title compound, m/e (CI+)=539 (M+H), (CI-)=537 (M-H).

Provenance & Evidence