2,5-Dibromo-3-chloropyridine → 5-Bromo-2-(4-tert-butyldiphenylsilyloxyphenyl)-3-chloropyridine

HRID 1780070Notes

Reaction equation

HRID 1780070 reaction equation
Br[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([Br:9])=[CH:4][N:3]=1.[Si:10]([O:27][C:28]1[CH:33]=[CH:32][C:31](B(O)O)=[CH:30][CH:29]=1)([C:23]([CH3:26])([CH3:25])[CH3:24])([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[Br:9][C:5]1[CH:6]=[C:7]([Cl:8])[C:2]([C:31]2[CH:30]=[CH:29][C:28]([O:27][Si:10]([C:23]([CH3:26])([CH3:25])[CH3:24])([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[CH:33][CH:32]=2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 126309832,5-Dibromo-3-chloropyridineHCID 218072914-Tert-butyldiphenylsilyloxybenzeneboronic acid

Product 1

HCID 190499865-Bromo-2-(4-tert-butyldiphenylsilyloxyphenyl)-3-chloropyridine

Procedure

5-Bromo-2-(4-tert-butyldiphenylsilyloxyphenyl)-3-chloropyridine is prepared analogously to Example 1 from 2,5-dibromo-3-chloropyridine and 4-tert-butyldiphenylsilyloxybenzeneboronic acid. ##STR29##

Sources & evidence

ORD record
ord-f406fd0f57de46839f004cd7817f1e89
Source dataset
uspto-grants-1997_05
Patent number
US05629428

Reaction notes

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