Sodium Chloride → HCID 136096333, compound

Participants

Reaction Steps

4.30 g (8.00 mmol) of 2-(4-tert-butyldiphenylsilyloxyphenyl)-3-chloro-5-octyloxypyridine are stirred at room temperature for 2 hours with 16 ml of a 1-molar tetrabutylammonium fluoride solution in tetrahydrofuran in 50 ml of tetrahydrofuran. Agueous sodium chloride solution is subsequently added, the mixture is extracted with ether, the ether phase is washed with aqueous sodium chloride solution, dried over sodium sulfate and evaporated to dryness, and the product is purified by chromatography (silica gel/hexane:ethyl acetate 8:2), giving 2.16 g of 3-chloro-2-(4-hydroxyphenyl)-5-octyloxypyridine. ##STR32##

Provenance & Evidence