Citric Acid → HCID 19050064, compound

Participants

Reaction Steps

In 4 ml of methanol, was suspended 225 mg (0.4 mmol) of methyl 1-acetoxymethyl-5-benzyloxy-3-t-butoxycarbonyl-7-trifluoromethyl-1,2,3,6-tetrahydropyrrolo[3,2-e]indole-8-carboxylate. Thereto 110.6 mg (0.8 mmol) of potassium carbonate was added, and the mixture was stirred for 7 hours. It was neutralized with 10% citric acid, and diluted with water. The precipitated crystalline matter was collected by filtration, washed with water, and dried. Thereby, methyl 5-benzyloxy-3-t-butoxycarbonyl-1-hydroxymethyl-7-trifluoromethyl-1,2,3,6-tetrahydropyrrolo[3,2-e]indole-8-carboxylate was prepared in a colorless crystalline state in a yield of 206.5 mg (99%).

Provenance & Evidence