N,N-Dimethylglycine hydrochloride → HCID 57137629, compound

Participants

Reaction Steps

Methyl (1S)-1-chloromethyl-3-[5 (dimethylaminomethylcarbonyl)amino-1H-indol-2-ylcarbonyl]-5-hydroxy-7-trifluoromethyl-1,2,3,6-tetrahydropyrrolo[3,2-e]indole-8-carboxylate was prepared from 12.1 mg (20 μmol) of methyl (1S)-3-[5-(t-butoxycarbonyl)amino-1H-indol-2-ylcarbonyl]-1-chloromethyl-5-hydroxy-7-trifluoromethyl-1,2,3,6-tetrahydropyrrolo[3,2-e]indole-8-carboxylate and 2.8 mg (20 μmol) of N, N-dimethylglycine hydrochloride in the same manner as in Example 6 in a yield of 7.8 mg (66%).

Provenance & Evidence