1-(2-Hydroxyethyl)piperazine → HCID 86750817, compound

Participants

Reaction Steps

Methyl (1S)-1-chloromethyl-5-[4-(2-hydroxyethyl)piperazin-1-ylcarbonyl)oxy-3-[5-(7-methoxybenzofuran-2-ylcarbonyl)amino]-1H-indol-2-ylcarbonyl]-7-trifluoromethyl-1,2,3,6-tetrahydropyrrolo[3,2-e]indole-8-carboxylate hydrochloride was prepared by using 25.6 mg (37 μmol) of methyl (1S)-1-chloromethyl-5-hydroxy-3-[5-(7-methoxybenzofuran-2-ylcarbonyl)amino-1H-indol-2-ylcarbonyl]-7-trifluoromethyl-1,2,3,6-tetrahydropyrrolo[3,2-e]indole-8-carboxylate and 6.8 μl (56 μmol) of 1-(2-hydroxyethyl)piperazine in the same manner as in Example 46 in a yield of 22.2 mg (69%).

Provenance & Evidence