HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(Carbamoylmethyl)-5-methylhexanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Dihydro-4-(2-methylpropyl)-2H-pyran-2,6(3H)-dione | HCID 11480690 | — |
| Product | 3-(Carbamoylmethyl)-5-methylhexanoic acid | HCID 10867083 | — |
Reaction Steps
In another step of the method, 3-isobutylglutaric acid anhydride is reacted with ammonia to form (±)-3-(carbamoylmethyl)-5-methylhexanoic acid. In this step, the cyclic anhydride is opened and one of the carbonyl groups is converted to an amide. (±)-3-(carbamoyl methyl)-5-methylhexanoic acid can be recrystallized from a number of solvents including ethyl acetate, water, chloroform and 2-butanone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05629447 |
| Source dataset | uspto-grants-1997_05 |
| ORD ID | ord-56591bc11fc544b885a5aa59ae691542 |
| Source note | uspto-grants-1997_05 |