(2S,3S)-3-(N2-benzyloxycarbonyl-L-asparaginyl)amino-2-hydroxy-4-phenylbutyric acid → (2S)-N-((1S,2S)-3-{(2S,4S)-2-[N-(tert-butyl)carbamoyl]-4-fluoropyrrolidinyl}-2-hydroxy-3-oxo-1-benzylpropyl)-3-carbamoyl-2-[(phenylmethoxy)carbonylamino]propanamide

Participants

Reaction Steps

Following a procedure similar to that described in Example 1, but using 222 mg (0,5 mmol) of (2S,3S)-3-(N2 -benzyloxycarbonyl-L-asparaginyl)amino-2-hydroxy-4-phenylbutyric acid and 144 mg (0.5 mmol) of (4S)-N-t-butoxycarbonyl-4-fluoro-N-t-butyl-L-prolinamide, 120 mg of the title compound were obtained as a colorless powder, melting at 95°-100° C.

Provenance & Evidence