1-Benzylpiperazine → HCID 86750832, compound

HRID 1780261Notes

Reaction equation

HRID 1780261 reaction equation
BrCC(N[C:6]1[CH:48]=[CH:47][C:9]([O:10][CH2:11][C:12]([NH:14][C@H:15]([C:20]([NH:22][C@@H:23]([CH2:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[C@H:24]([OH:39])[C:25]([N:27]2[CH2:38][CH2:37][CH2:36][C@H:28]2[C:29]([NH:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[O:26])=[O:21])[CH2:16][C:17](=[O:19])[NH2:18])=[O:13])=[CH:8][CH:7]=1)=O.[CH2:49]([N:56]1[CH2:61][CH2:60][NH:59][CH2:58][CH2:57]1)[C:50]1[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=1>>[CH2:49]([N:56]1[CH2:61][CH2:60][N:59]([C:6]2[CH:48]=[CH:47][C:9]([O:10][CH2:11][C:12]([NH:14][C@H:15]([C:20]([NH:22][C@@H:23]([CH2:40][C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)[C@H:24]([OH:39])[C:25]([N:27]3[CH2:38][CH2:37][CH2:36][C@H:28]3[C:29]([NH:31][C:32]([CH3:34])([CH3:33])[CH3:35])=[O:30])=[O:26])=[O:21])[CH2:16][C:17](=[O:19])[NH2:18])=[O:13])=[C:8]([NH:14][C:12](=[O:13])[CH3:11])[CH:7]=2)[CH2:58][CH2:57]1)[C:50]1[CH:51]=[CH:52][CH:53]=[CH:54][CH:55]=1

Participants

3

Reactant 2

HCID 759941-BenzylpiperazineHCID 86750830HCID 86750830, compound

Product 1

HCID 86750832HCID 86750832, compound

Procedure

Following a procedure similar to that described in Example 38, but using 100 mg (0.137 mmol) of 1-{(2S,3S)-3-[N2 -(4-bromoacetamidophenoxy)acetyl-L-asparaginyl]amino-2-hydroxy-4-phenylbutyryl}-N-t-butyl-L-prolinamide and 1 ml of 1-benzylpiperazine, 60 mg of the title compound were obtained as a colorless powder, melting at 119°-127° C.

Sources & evidence

ORD record
ord-57ac65fdb9b14aa6aa8be03a2b555ae1
Source dataset
uspto-grants-1997_05
Patent number
US05629406

Reaction notes

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