N-Cbz-L-2-amino-4-sulfamoylbutyric acid → (4S)-1-{(2S,3S)-3-[2(S)-Benzyloxycarbonylamino-4-sulfamoylbutyryl]amino-2-hydroxy-4-phenylbutyryl}-4-chloro-N-t-butyl-L-prolinamide

Participants

Reaction Steps

Following a procedure similar to that described in Example 66, but using 122 mg (0.32 mmol) of (4S)-1-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutyryl]-4-chloro-N-t-butyl-L-prolinamide [prepared as described in Preparation 21(b)] and 100 mg (0.32 mmol) of (S)-2-benzyloxycarbonylamino-4-sulfamoylbutyric acid, 169 mg of the title compound were obtained as a colorless powder, melting at 115°-122° C.

Provenance & Evidence