Formaldehyde → HCID 86750834, compound

HRID 1780267Notes

Reaction equation

HRID 1780267 reaction equation
[CH2:1]([NH:8][C@H:9]([C:14]([NH:16][C@@H:17]([CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[C@H:18]([OH:33])[C:19]([N:21]1[CH2:32][CH2:31][CH2:30][C@H:22]1[C:23]([NH:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])=[O:20])=[O:15])[CH2:10][C:11](=[O:13])[NH2:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:41]=O>>[CH2:1]([N:8]([CH3:41])[C@H:9]([C:14]([NH:16][C@@H:17]([CH2:34][C:35]1[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1)[C@H:18]([OH:33])[C:19]([N:21]1[CH2:32][CH2:31][CH2:30][C@H:22]1[C:23]([NH:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])=[O:20])=[O:15])[CH2:10][C:11](=[O:13])[NH2:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 70048814HCID 70048814, compound

Product 1

HCID 86750834HCID 86750834, compoundYield 73.2%

Procedure

Following a procedure similar to that described in Example 67, but using 200 mg (0.36 mmol) of 1-[(2S,3S)-3-(N2 -Benzyl-L-asparaginyl)amino-2-hydroxy-4-phenylbutyryl]-N-t-butyl-L-prolinamide (prepared as described in Example 86) and 41 μl (0.54 mmol) of 37% formalin, 149 mg of the title compound were obtained as a colorless powder, melting at 97°-100° C.

Sources & evidence

ORD record
ord-7374d739cbc541f9a6cc79f7dc65d30e
Source dataset
uspto-grants-1997_05
Patent number
US05629406

Reaction notes

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