2-Benzyloxycarbonylamino-3-(tetrahydrofuran-2-yloxy)propionic acid → (4S)-1-[(2S,3S)-3-{N2-[2(S)-Benzyloxycarbonylamino-3-(tetrahydrofuran-2-yloxy)propanoyl]-L-asparaginyl}amino-2-hydroxy-4-phenylbutyryl]-4-chloro-N-t-butyl-L-prolinamide

Participants

Reaction Steps

Following a procedure similar to that described in Example 16, but using 100 mg (0.26 mmol) of (4S)-1-[2S,3S)-3-(N2 -t-butoxycarbonyl-L-asparaginyl)amino-2-hydroxy-4-phenylbutyryl]-4-chloro-N-t-butyl-L-prolinamide (prepared as described in Example 65) and 2-benzyloxycarbonylamino-3-(tetrahydrofuran-2-yloxy)propionic acid, 83 mg of the title compound were obtained as a colorless powder, melting at 64°-71° C.

Provenance & Evidence