Formic Acid → 5-Phenyl-6-chloro-3(1-methyl-2-(S)-azetidinylmethoxy)pyridine hydrochloride

HRID 1780341Notes

Reaction equation

HRID 1780341 reaction equation
[C:1]1([C:7]2[CH:8]=[C:9]([O:14][CH2:15][C@@H:16]3[CH2:19][CH2:18][NH:17]3)[CH:10]=[N:11][C:12]=2[Cl:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C=O.[CH:22](O)=O.[BH3-]C#N.[Na+]>C(O)C.O.C([O-])([O-])=O.[K+].[K+]>[ClH:13].[C:1]1([C:7]2[CH:8]=[C:9]([O:14][CH2:15][C@@H:16]3[CH2:19][CH2:18][N:17]3[CH3:22])[CH:10]=[N:11][C:12]=2[Cl:13])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

8

Reactant 4

HCID 284Formic AcidHCID 712FormaldehydeHCID 5003444Sodium cyanoborohydrideHCID 98397025-phenyl-6-chloro-3-(2-(S)-azetidinylmethoxy)pyridine

Product 1

HCID 228726895-Phenyl-6-chloro-3(1-methyl-2-(S)-azetidinylmethoxy)pyridine hydrochloride

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 962WaterSolventHCID 11430Potassium CarbonateSolvent

Procedure

To 5-phenyl-6-chloro-3-(2-(S)-azetidinylmethoxy)pyridine from Example 67 (100 mg, 0.36 mmol) in ethanol (3 mL) was added formalin (37%, 0.5 mL) and formic acid (0.25 mL), and the pH was adjusted to 6. Then NaCNBH3 (70 mg) was added, and the mixture was stirred at room temperature for 16 hours. The mixture was diluted with water and saturated with K2CO3. The mixture was extracted with chloroform. The solvent was dried over MgSO4, filtered and concentrated. The residue was chromatographed on a silica gel column, eluting with methylene chloride:methanol 10:1 to afford the free base of the title compound. MS (DCI/NH3) m/z 289 (M+H)+. 1H NMR (CDCl3, 300 MHz) δ2.05-2.14 (m, 2H), 2.40 (s, 3H), 2.32-2.44 (m, 1H), 3.34-3.51 (m, 2H), 4.44 (d, J=7.5 Hz, 2H), 7.26 (d, J=3 Hz, 1H), 8.09 (d, J=3 Hz, 1H). The salt was prepared by treatment with HCl in ether, as described above, to give the title compound. mp 187°-188° C. MS (DCI/NH3) m/z 289 (M+H)+. 1H NMR (D2O, 300 MHz) δ: 2.60-2.71 (m, 2H), 2.99 (s, 3H), 3.94-4.12 (m, 1H), 4.18-4/33 (m, 1H), 4.47-4.55 (m, 3H), 7.57 (m, 5H), 7.60 (d, J=3.0 Hz, 1H), 8.18 (d, J=3.0 Hz, 1H). Anal. Calcd for C16H17N2OCl·HCl·0.5 H2O: C, 57.50; H, 5.73; N, 8.38. Found: C, 57.38; H, 5.53; N, 8.35. [α]25D =+15° (c 0.11, MeOH).

Workup

  1. extractionThe mixture was extracted with chloroform
  2. dry with materialThe solvent was dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customThe residue was chromatographed on a silica gel column
  6. washeluting with methylene chloride:methanol 10:1

Sources & evidence

ORD record
ord-9b0e15941ef04cb495a19ef2ac9fde68
Source dataset
uspto-grants-1997_05
Patent number
US05629325

Reaction notes

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