Methyl iodide → HCID 53923894, compound

HRID 1780433Notes

Reaction equation

HRID 1780433 reaction equation
[CH3:1][C@@:2]12[C:11]3[CH:12]=[CH:13][C:14]([S:16][C:17]4[S:18][C:19]5[CH:25]=[CH:24][CH:23]=[CH:22][C:20]=5[N:21]=4)=[CH:15][C:10]=3[CH2:9][CH2:8][C@H:7]1[NH:6][C:5](=[O:26])[CH2:4][CH2:3]2.[CH3:27]I>>[CH3:27][N:6]1[C@H:7]2[C@@:2]([CH3:1])([C:11]3[CH:12]=[CH:13][C:14]([S:16][C:17]4[S:18][C:19]5[CH:25]=[CH:24][CH:23]=[CH:22][C:20]=5[N:21]=4)=[CH:15][C:10]=3[CH2:9][CH2:8]2)[CH2:3][CH2:4][C:5]1=[O:26]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 54528624HCID 54528624, compound

Product 1

HCID 53923894HCID 53923894, compound

Procedure

A 170 mg portion of (4aR)-(10bR)-10b-methyl-8-(2-benzothiazolylthio)-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one was alkylated with methyl iodide substantially according to the process of Example 95 to obtain 84 mg of the desired product. mp 188°-189° FDMS: m/e=394.

Sources & evidence

ORD record
ord-77832217ec4a4738b8ba50aa3f85d5d5
Source dataset
uspto-grants-1997_05
Patent number
US05629007

Reaction notes

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