反应详情

温度

0 °C

1.2 ml (7.1 mmol) of octanoyl chloride are added dropwise at 0° C. to 1.5 g (4.7 mmol) of 2-fluoro-3-hydroxy-6-(4-octyloxyphenyl)pyridine (prepared as described in Example 3) in 20 ml of pyridine, and the mixture is stirred at 0° C. for 3 hours. It is then poured onto ice water, filtered off and the residue is purified by chromatography (silica gel, 9:1 hexane/ethyl acetate) and by recrystallization from acetonitrile, giving 1.34 g of 2-fluoro-6-(4-octyloxyphenyl)pyridine-3-yl octanoate. ##STR20##

1. additionIt is then poured onto ice water
2. filtrationfiltered off
3. customthe residue is purified by chromatography (silica gel, 9:1 hexane/ethyl acetate) and by recrystallization from acetonitrile