Dicyclohexylcarbodiimide → HCID 178443712, compound

Participants

Reaction Steps

0.29 g (0.91 mmol) of 2-fluoro-3-hydroxy-6-(4-octyloxyphenyl)pyridine (prepared as described in Example 3), 0.19 g (0.91 mmol) of dicyclohexylcarbodiimide, 0.16 g (0.91 mmol) of trans-4-pentylcyclohexanecarboxylic acid and 0.01 g of 4-(N,N-dimethylamino)pyridine are stirred in 10 ml of methylene chloride at room temperature for 18 hours. Filtration, evaporation to dryness, purification by chromatography (silica gel, 8:2 hexane/ethyl acetate) and recrystallization from acetonitrile give 0.19 g of 2-fluoro-6-(4-octyloxyphenyl)pyridin-3-yl trans-4-pentylcyclohexanecarboxylate. ##STR40##

Provenance & Evidence