Acetone → HCID 54357790, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 12 g of the 7-chloro-2,3-dihydro-2,2,4,5-tetramethyl-benzo-furan-6-carboxaldehyde in 25 ml of acetone was added 8 ml of water and 2 ml of 10% aqueous solution of sodium hydroxide. After refluxing at 40° C. for 15 hours, the reaction mixture was quenched with 2N aqueous solution of hydrochloric acid and the aqueous layer was extracted with diethyl ether. The combined organic extracts were dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford a crude product. Final purification was carried by silica-gel column chromatography to afford 10 g of 4-(7-chloro-2,3-dihydro-2,2,4,5-tetramethyl-benzofuran-6-yl)-3-buten-2-one

Provenance & Evidence