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Ethanol → n-(5-Amino-2-methoxyphenyl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 2-Methoxy-5-nitroaniline | HCID 7447 | — |
| 反応物 | AcOH AcOAc | HCID 21895370 | — |
| 触媒 | Adams' catalyst | HCID 345198 | — |
| 溶媒 | Oxolane--water (1/1) | HCID 21881883 | — |
| 生成物 | n-(5-Amino-2-methoxyphenyl)acetamide | HCID 267867 | — |
反応手順
2-Methoxy-5-nitroaniline was purchased and acetylated using HOAc/Ac2O in H2O/THF according to known procedures to make 2-methoxy-5-nitroacetanilide. This was reduced using catalytic hydrogenation (PtO2, H2, EtOH) to afford 3-acetamido-4-methoxyaniline which was reacted as described in Examples 1 and 2 to yield the desired glutarimide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05631209 |
| 出典データセット | uspto-grants-1997_05 |
| ORD ID | ord-f6080562979b47b98686940f0c7378ca |
| 出典メモ | uspto-grants-1997_05 |