Water → HCID 19047231, compound

HRID 1780696Notes

Reaction equation

HRID 1780696 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14].[C:16](Cl)(=[O:20])[CH2:17][CH2:18][CH3:19].C(Cl)(Cl)Cl.O>N1C=CC=CC=1>[C:16]([O:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])(=[O:20])[CH2:17][CH2:18][CH3:19]

Participants

6

Reactant 4

HCID 962WaterHCID 6212ChloroformHCID 8855Butyryl chlorideHCID 7903412-Hydroxydodecanoic Acid

Product 1

HCID 19047231HCID 19047231, compoundYield 96.7%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

12-Hydroxydodecanoic acid (1 g) was dissolved in pyridine, and butyroyl chloride (0.59 g) was added to the solution in an ice bath. After 4 hours of stirring, the reaction mixture was distributed into chloroform and water, and the chloroform layer was concentrated to give 12-butyryloxydodecanoic acid (1.28 g).

Workup

  1. concentrationthe chloroform layer was concentrated

Sources & evidence

ORD record
ord-55281f1cf81b44dc9b8868b0f77d3916
Source dataset
uspto-grants-1997_05
Patent number
US05631238

Reaction notes

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