HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 4-(3-Iodopropoxy)benzoic acid, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Methyl 4-(3-chloropropoxy)benzoate | HCID 12389265 | — |
| Reactant | 4-[3-[4-[(2-Benzothiazolyl)carbonyl]-1-piperidinyl]propoxy]benzoic acid methyl ester | HCID 15337463 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4-(3-Iodopropoxy)benzoic acid, methyl ester | HCID 15337462 | — |
Reaction Steps
4-[3-[4-[(2-Benzothiazolyl)carbonyl]-1-piperidinyl]propoxy]benzoic acid, methyl ester ##STR22## Dissolve 4-(3-chloropropoxy)benzoic acid, methyl ester (6.97 g, 30.5 mmol) in anhydrous acetone (100 mL) and add powdered sodium iodide (16.0 g, 107 mmol). Heat at reflux under an argon atmosphere for 38 hours. Dilute with ethyl ether (100 mL) and filter through Celite® filter aid. Wash the filtrate with water and brine, then dry (MgSO4). Evaporate the solvent in vacuo to give 4-(3-iodopropoxy)benzoic acid, methyl ester as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05631268 |
| Source dataset | uspto-grants-1997_05 |
| ORD ID | ord-b55a5b56ecd6472eb1f52e0aa86fe4a7 |
| Source note | uspto-grants-1997_05 |