Trifluoroacetic acid → HCID 19047660, compound

Participants

Reaction Steps

To compound 11 (0.15 g) was added triethylsilane (0.36 mL) and trifluoroacetic acid (10 mL). After stirring for 10 min. the solution was concentrated in vacuo and the residue was partitioned between ethyl acetate and sodium bicarbonate. The ethyl acetate layer was washed with saturated sodium chloride, dried over magnesium sulfate and concentrated in vacuo to afford the crude product. Trituration with hexane/ethyl acetate 8/2 gave the product. NMR (300 MHz, CDCl3) δ 7.62 (1H, d, J=3 Hz), 7.53 (1H, s), 7.13 (2H, q, J=3 Hz), 7.04 (2H, m), 6.77 (1H, d, J=3 Hz), 3.62 (2H, t, J=3 Hz), 3.39 (2H, t, J=3 Hz), 2.33 (3H, s), 2.21 (3H, s).

Provenance & Evidence