HCID 19707490, compound → Methyl 3-(3-aminophenoxy)benzoate

HRID 1780821Notes

Reaction equation

HRID 1780821 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([O:11][C:12]2[CH:13]=[C:14]([N+:18]([O-])=O)[CH:15]=[CH:16][CH:17]=2)[CH:8]=[CH:9][CH:10]=1)([O:3][CH3:4])=[O:2]>CO.[Pd]>[C:1]([C:5]1[CH:6]=[C:7]([O:11][C:12]2[CH:13]=[C:14]([NH2:18])[CH:15]=[CH:16][CH:17]=2)[CH:8]=[CH:9][CH:10]=1)([O:3][CH3:4])=[O:2]

Participants

4

Reactant 1

HCID 19707490HCID 19707490, compound

Product 1

HCID 19707463Methyl 3-(3-aminophenoxy)benzoate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 41 (440 mg) in 30 mL of methanol under a nitrogen atmosphere was added 10% Pd/C (30 mg). The solution was purged with H2 gas, then stirred at room temperature under a balloon atmosphere of H2. After 8 h, the reaction was flushed with nitrogen and filtered through celite to remove the catalyst, then concentrated in vacuo. The resulting brown oil was used without further purification.

Workup

  1. customThe solution was purged with H2 gas
  2. customthe reaction was flushed with nitrogen
  3. filtrationfiltered through celite
  4. customto remove the catalyst
  5. concentrationconcentrated in vacuo
  6. customThe resulting brown oil was used without further purification

Sources & evidence

ORD record
ord-d023a98feec84e08ba522c49b602c4f9
Source dataset
uspto-grants-1997_05
Patent number
US05631280

Reaction notes

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