1-Ethenyl-3-methylbenzene → HCID 19047738, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-bromoaniline (545 uL), 3-methylstyrene (780 uL), tri(o-tolyl)phosphine (60 mg), Pd(OAc)2 (10 rag), and triethylamine (2.5 mL) was prepared in a sealed tube under argon atmosphere. The reaction was heated at 100° C. for 4 h, then cooled to room temperature and poured into ethyl acetate and water. The organic layer was washed with water and dried (Na2SO4), filtered, and concentrated in vacuo to provide the crude product. Purification by silica gel chromatography (20:1-5:1 hexane/EtOAc) provided the titled compound.

Provenance & Evidence