3-Nitrophenol → HCID 19047749, compound

Participants

Reaction Steps

To a solution of 3-nitrophenol (200 mg) in 4.0 mL of dimethylformamide at 0° C. was added NaH. After 10 minutes, 1-bromomethylnaphthalene (480 mg) was added, and the cold bath was removed. After ca. 15 h, the solution was quenched by the addition of sat. NH4Cl solution, and concentrated to dryness in vacuo. The residue was diluted with ethyl acetate and washed with water, sat. aq. NaHCO3 solution, and brine. The solution was dried (MgSO4), filtered, and concentrated in vacuo to provide the crude product. Trituration with 9:1 hexane/EtOAc provided the titled compound as a light brown solid.

Provenance & Evidence