p-Toluenesulfonic acid → HCID 15295203, compound

Participants

Reaction Steps

A mixture of 4-(3,4-bisdifluoromethoxyphenyl)-4-ethynylcyclohexan-1-one dimethyl ketal (0.2 g, 0.53 mmol) and p-toluenesulfonic acid (catalytic amount) in acetone (10 mL) was stirred under an argon atmosphere at room temperature for 0.5 h. The mixture was concentrated, was diluted with methylene chloride and was washed with water. The organic extract was dried (magnesium sulfate) and the solvent was removed in vacuo to provide an oil (0.17 g, 98%). Analysis Calc. for C16H14F4O3 : C 58.19, H 4.27; found: C 58.30, H 4.40.

Provenance & Evidence