Ammonium Chloride → HCID 19047579, compound

Participants

Reaction Steps

To a solution of 9.38 g (0.057 mol) of 4-methoxy-1-indanone in 250 mL of ether cooled to 0° C. was added dropwise over 5 rain 33.72 mL (0.0607 mol) of 1.8 M phenyllithium in cyclohexane/ether and the mixture was stirred at room temperature for 1 h. An additional (10 mL) phenyllithium solution was added and stirred at room temperature for 1 h. To the reaction mixture was added saturated ammonium chloride solution and the resulting mixture was extracted with ethyl acetate (3×100 mL), and the organic layer was washed with brine, dried over sodium sulfate and concentrated in vacuo to afford 14.3 g of crude 4-methoxy-1-phenyl-indan-1-ol which was used directly in the next step without further purification.

Provenance & Evidence