2-(1H-imidazol-2-yl)ethan-1-ol → N-(4-(1-(2,6-difluorobenzyl)-5-(((2-(2-(2-hydroxyethyl)-1H-imidazol-1-yl)ethyl)(methyl)amino)methyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N'-ethylurea

HRID 178088Notes

Reaction equation

HRID 178088 reaction equation
[F:1][c:2]1[c:3]([CH2:4][n:5]2[c:6](=[O:39])[n:7](-[c:33]3[cH:34][cH:35][cH:36][cH:37][cH:38]3)[c:8](=[O:32])[c:9]3[c:10]2[s:11][c:12](-[c:20]2[cH:21][cH:22][c:23]([NH:26][C:27](=[O:28])[NH:29][CH2:30][CH3:31])[cH:24][cH:25]2)[c:13]3[CH2:14][N:15]([CH3:16])[CH2:17][CH2:18][OH:19])[c:40]([F:44])[cH:41][cH:42][cH:43]1.[OH:45][CH2:46][CH2:47][c:48]1[nH:49][cH:50][cH:51][n:52]1>>[F:1][c:2]1[c:3]([CH2:4][n:5]2[c:6](=[O:39])[n:7](-[c:33]3[cH:34][cH:35][cH:36][cH:37][cH:38]3)[c:8](=[O:32])[c:9]3[c:10]2[s:11][c:12](-[c:20]2[cH:21][cH:22][c:23]([NH:26][C:27](=[O:28])[NH:29][CH2:30][CH3:31])[cH:24][cH:25]2)[c:13]3[CH2:14][N:15]([CH3:16])[CH2:17][CH2:18][n:49]2[c:48]([CH2:47][CH2:46][OH:45])[n:52][cH:51][cH:50]2)[c:40]([F:44])[cH:41][cH:42][cH:43]1

Participants

3

Reactant 2

HCID 150160802-(1H-imidazol-2-yl)ethan-1-olHCID 68893898N-(4-(1-(2,6-difluorobenzyl)-5-(((2-hydroxyethyl)(methyl)amino)methyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N'-ethylurea

Product 1

HCID 57794259N-(4-(1-(2,6-difluorobenzyl)-5-(((2-(2-(2-hydroxyethyl)-1H-imidazol-1-yl)ethyl)(methyl)amino)methyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N'-ethylurea

Sources & evidence

ORD record
ord-4d04dc0e2c974618aef4c2254f3edec8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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