Pyrido[1,2-b]isoquinolin-5-ium perchlorate → HCID 22356189, compound

Participants

Reaction Steps

A reaction mixture containing benzo[b]quinolizinium perchlorate (9.5 g; 6.8 mmol) and 1,1-di-[(1-p-methoxybenzyl)-pyrazol-3-yl)ethylene (14.9 g; 0.034 mol) in 300 mL of nitromethane was refluxed for 16 h under nitrogen. The reaction mixture was concentrated in vacuo, the residue was triturated with 400 mL of methanol, and the solid was filtered, and dried (60° C.) to afford 22.1 g (85.6%) of 6,11-ethano-12,12-di-[(1-p-methoxybenzyl) pyrazol-3-yl)]-6,11-dihydrobenzo[b]quinolizinium perchlorate (Formula I: R1 =R2 =R3 =R4 =R7 =H ;R5 =R6 =1-p-methoxybenzyl-3-pyrazolyl;X- =ClO4-), as a solid.

Provenance & Evidence