HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl isoquinoline-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Isoquinoline-1-carboxylic acid | HCID 68092 | — |
| Product | Methyl isoquinoline-1-carboxylate | HCID 21196988 | 50% |
Reaction Steps
A mixture of 1-isoquinolinecarboxylic acid (25 g.0.14 mol), 25 g of AMBERLYST®-15 (H+), and 300 ml of methanol was refluxed for 3 days. The reaction mixture was cooled, filtered, and the filtrate was concentrated in vacuo to afford 13.6 g (50%) of 1-isoquinolinecarboxylic acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05631264 |
| Source dataset | uspto-grants-1997_05 |
| ORD ID | ord-a06452d4ab3e4671a5bd9c4e53382385 |
| Source note | uspto-grants-1997_05 |