HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl isoquinoline-1-carboxylate → Isoquinoline-1-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl isoquinoline-1-carboxylate | HCID 21196988 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Isoquinoline-1-carbaldehyde | HCID 265306 | 64% |
Reaction Steps
1-Isoquinolinecarboxaldehyde (7.3 g, 64 %) was prepared from 1-isoquinolinecarboxylic acid methyl ester (13.6 g, 0.073 mol) and 1M LAH (36.6 ml in THF) in 300 ml of dry THF (J. Org. Chem., vol 28, p 1898, 1963) to afford 7.3 g (64%) of 1-isoquinolinecarboxaldehyde.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05631264 |
| Source dataset | uspto-grants-1997_05 |
| ORD ID | ord-1ad88c5ca76c4d329b8bf085bdb1345f |
| Source note | uspto-grants-1997_05 |