反应详情

To a solution of 194.0 g (0.56 mol) of 15 in 450 mL of water is added sufficient NaOH to adjust the pH to 12.0 to 12.5 (the temperature is maintained below 30° C. during the addition). Propylene oxide (65 g, 1.12 mols) is added to the basic solution. After 6 hours at ambient temperature the excess propylene oxide and solvent is removed under reduced pressure. The product is precipitated from a minimal amount of methanol to afford 16 in 96% yield.

1. temperatureis maintained below 30° C. during the addition)
2. customAfter 6 hours at ambient temperature the excess propylene oxide and solvent is removed under reduced pressure
3. customThe product is precipitated from a minimal amount of methanol