HCID 13987528, compound → HCID 53639898, compound

HRID 1780965Notes

Reaction equation

[C:1]1([C:7]2([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C@H:15]3[C@H:11]([CH2:12][NH:13][CH2:14]3)[C@:10]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[O:23][CH3:24])([OH:16])[C@H:9]([OH:25])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:32][O:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=1[C@@H:40]([CH3:44])[C:41](O)=[O:42]>>[C:26]1([C:7]2([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[C@H:15]3[C@H:11]([CH2:12][N:13]([C:41](=[O:42])[C@@H:40]([C:35]4[CH:36]=[CH:37][CH:38]=[CH:39][C:34]=4[O:33][CH3:32])[CH3:44])[CH2:14]3)[C@:10]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[O:23][CH3:24])([OH:16])[C@H:9]([OH:25])[CH2:8]2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

Reactant 2

HCID 13987528HCID 13987528, compound

HCID 54022323HCID 54022323, compound

Product 1

HCID 53639898HCID 53639898, compoundYield 43.2%

Procedure

By working according to the procedure of Example 1, starting from 0.2 g of (3aR,4R,5R,7aR)-7,7-diphenyl-4-(2-methoxyphenyl)perhydro-4,5-isoindolediol and 0.11 g of (R)-2-(2-methoxyphenyl) propionic acid, 0.12 g of (3aR,4R,5R,7aR)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(R)-2-(2-methoxyphenyl) propionyl]perhydro-4,5-isoindolediol is obtained, melting at 178°-180° C.

Sources & evidence

ORD record: ord-71e76fe394b94ca08d51895d1070f820
Source dataset: uspto-grants-1997_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05631279

Reaction notes

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