(3aRS,4RS,5RS,7aRS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydro-4,5-isoindolediol → HCID 67718910, compound

HRID 1780974Notes

Reaction equation

HRID 1780974 reaction equation
[C:1]1([C:7]2([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH:15]3[CH:11]([CH2:12][NH:13][CH2:14]3)[C:10]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[O:23][CH3:24])([OH:16])[CH:9]([OH:25])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:32]1([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=2[CH2:43][C:44](O)=[O:45])[CH2:36][CH2:35][CH2:34][CH2:33]1>>[C:26]1([C:7]2([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH:15]3[CH:11]([CH2:12][N:13]([C:44](=[O:45])[CH2:43][C:38]4[CH:39]=[CH:40][CH:41]=[CH:42][C:37]=4[N:32]4[CH2:36][CH2:35][CH2:34][CH2:33]4)[CH2:14]3)[C:10]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[O:23][CH3:24])([OH:16])[CH:9]([OH:25])[CH2:8]2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 19047650(3aRS,4RS,5RS,7aRS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydro-4,5-isoindolediolHCID 230093992-[2-(Pyrrolidin-1-yl)phenyl]acetic acid

Product 1

HCID 67718910HCID 67718910, compoundYield 77.8%

Procedure

By working according to the procedure of Example 1, starting from 0.62 g of (3aRS,4RS,5RS,7aRS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydro-4,5-isoindolediol and 0.40 g of 2-(1-pyrrolidinyl)phenylacetic acid, 0.70 g of (3aRS,4RS,5RS,7aRS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(2-(1-pyrrolidinyl)phenyl)acetyl]perhydro-4,5-isoindolediol is obtained, melting at 236° C.

Sources & evidence

ORD record
ord-cd22a7b3952a4e9c87a905c978cab9b6
Source dataset
uspto-grants-1997_05
Patent number
US05631279

Reaction notes

Loading…