Nitric Acid → 1-Bromo-2,5-dichloro-4-nitrobenzene

Participants

Reaction Steps

A solution of 2-bromo-1,4-dichlorobenzene (1.000 g, 4.443 mmol, Aldrich, used as received) in fuming HNO3 (7.0 mL) was stirred at 50° C. for 1.5 h and poured into ice (80 g). Yellowish white solid was filtered, washed with water (10 mL), and dried under vacuum to obtain 1.14 g (95%) of pure (1H NMR) title compound as a yellowish white powder; m.p. 50°-53° C. (lit m.p. 57°-58° C.; Fox, D. L. and Turner, E. E., J. Chem. Soc. 1859 (1930)); 1H NMR (CDCl3): δ7.863 (s, 1H), 8.030 (s, 1H). This material was used as such for the next reaction.

Provenance & Evidence