HRID1781109

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

HCID10966294

Acetamide, 2-chloro-N-(4-fluorophenyl)-N-(1-methylethyl)-

C11H13ClFNO

PRODUCTS

生成物

HCID6452934

N-(4-Fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamide

C11H14FNO2

CONDITIONS

反应条件

温度: 100 °C

PROCEDURE

实验过程

In a 500 ml flask, 23.0 g (0.1 mol) of N-chloroacetyl-N-isopropyl-4-fluoroaniline and 11.7 g (0.11 mol) of sodium carbonate in 340 ml of solvent or solvent mixture are heated with stirring to reflux temperature (100° C.). The reaction is monitored by gas chromatography (sampling after in each case 1 hour). The results are compiled in the table which follows.

WORKUP

后处理

aliquotsampling after in each case 1 hour)