Methanesulfonyl chloride → HCID 19048030, compound

Participants

Reaction Steps

1-Fluoro-4-methanesulfonyl-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) 1,4-Diazabicyclo[2.2.2]octane (11 g, 10 mmol) in tetrahydrofuran (100 mL) is reacted with methanesulfonyl chloride (11.5 g, 10 mmol) until the reaction is complete by TLC. The reaction is evaporated, diluted with acetonitrile (100 mL) and sodium tetrafluoroborate (40 g, 20 mmol) added. The solution is stirred overnight at room temperature and then filtered to remove all undissolved salts. The filtrate is evaporated to afford 1-methanesulfonyl-4-aza-1-azoniabicyclo[2.2.2]octane tetrafluoroborate.

Provenance & Evidence