4-Phenoxybenzaldehyde → N-(2-Ethylthioethyl)-N-(4-phenoxybenzyl)amine
Reaction equation
[O:1]([C:8]1[CH:15]=[CH:14][C:11]([CH:12]=O)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH2:17]([S:19][CH2:20][CH2:21][NH2:22])[CH3:18]>>[CH2:17]([S:19][CH2:20][CH2:21][NH:22][CH2:12][C:11]1[CH:14]=[CH:15][C:8]([O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:9][CH:10]=1)[CH3:18]Participants
3
Procedure
Following the procedure described in Example 68A, 4-phenoxybenzaldehyde (1.98 g, 10 mmol) and 2-(ethylthio)ethylamine hydrogen chloride (1.42 g, 10 mmol) were combined to give the title compound (2.72 g, 95%). 1H NMR (300 MHz, CDCl3), δ 7.33 (m, 4 H), 7.09 (t, 1 H), 6.98 (m, 4 H), 3.78 (s, 2 H), 2.84 (t, 2 H), 2.71 (t, 2 H), 2.54 (q, 2 H), 1.26 (t, 3 H).
Sources & evidence
- ORD record
- ord-2584b6a8aff64f61a562814a6a8d559d
- Source dataset
- uspto-grants-1997_05
- Patent number
- US05631401
Reaction notes
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