Water → HCID 54387522, compound

Participants

Reaction Steps

A solution of the compound resulting from Example 82A (0.12 g, 0.63 mmol), n-propylamine (0.052 mL, 0.63 mmol), EDCl (0.14 g, 0.73 mmol), HOBT (0.02 g, 1.4 mmol), Et3N (0.10 mL, 0.73 mmol), and 3.5 mL anydrous THF was stirred at room temperature for 24 hours. Water was added, and the mixture was extracted with EtOAc (3×). The combined organic layers were washed with 5% sodium bicarbonate, H2O, 1N HCl and saturated NaCl solution, dried (MgSO4), filtered, and concentrated in vacuo to afford the title compound (0.13 g) as a colorless oil. 1H NMR (300 MHz, CDCl3) δ 0.90 (t, 3H), 1.12 (d, 3H), 1.38-1.58 (m, 3H), 1.59-1.78 (m, 3H), 2.15 (m, 1H), 2.60 (m, 2H), 3.20 (q, 2H), 5.35 (brs, 1H) 7.20 (t, 3H), 7.28 (m,2H). MS (DCl/NH3) m/e 234 (M+H)+.

Provenance & Evidence