Sodium Dithionite → HCID 178422420, compound

Participants

Reaction Steps

The title compound of Step C (25 g, 98 mmol) and sodium dithionite (38 g, 220 mmol) were suspended in a mixture of ethanol (1000 mL) and water (200 mL) at room temperature. After 1 h, most of the solvent was removed under reduced pressure. The residue was diluted with water and acidified with hydrochloric acid. Insolubles were removed by filtration. The filtrate was extracted twice with methylene chloride. The combined organic extracts were dried (MgSO4), filtered, and concentrated under reduced pressure to afford the title compound of Step D as a tan/yellow solid (15.29 g, 65%). 1H NMR (CDCl3): δ2.37 (s,3H), 7.5 (d,2H), 8.15 (s, 1H), 9.8 (br s, 1H).

Provenance & Evidence