Furosemide → HCID 68666232, compound

HRID 1781246Notes

Reaction equation

[CH:1]1[CH:2]=[C:3]([CH2:6][NH:7][C:8]2[C:13]([C:14]([OH:16])=[O:15])=[CH:12][C:11]([S:17]([NH2:20])(=[O:19])=[O:18])=[C:10]([Cl:21])[CH:9]=2)[O:4][CH:5]=1.[CH3:22][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:28]=1[N:29]1[C:38](=[O:39])[C:37]2[CH:36]=[C:35]([S:40]([NH2:43])(=[O:42])=[O:41])[C:34]([Cl:44])=[CH:33][C:32]=2[NH:31][CH:30]1[CH3:45]>>[CH3:22][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:28]=1[N:29]1[C:38](=[O:39])[C:37]2[CH:36]=[C:35]([S:40]([NH2:43])(=[O:41])=[O:42])[C:34]([Cl:44])=[CH:33][C:32]=2[NH:31][CH:30]1[CH3:45].[CH:1]1[CH:2]=[C:3]([CH2:6][NH:7][C:8]2[C:13]([C:14]([OH:16])=[O:15])=[CH:12][C:11]([S:17]([NH2:20])(=[O:19])=[O:18])=[C:10]([Cl:21])[CH:9]=2)[O:4][CH:5]=1

Participants

Reactant 2

HCID 3440Furosemide

HCID 4170Metolazone

Product 1

HCID 68666232HCID 68666232, compound

Procedure

Rats (450 g previously untreated) were intraperitoneally administered 0.5 ml of 4 mg/ml lasix solution (4 mg/kg dose) and 0.5 ml of 2 mg/ml metolazone/tris buffer solution, pH 11.5, (2 mg/kg dose). The results are shown in Table V below.

Sources & evidence

ORD record: ord-afe96e785cfc4f1c9f88cafef09f3c63
Source dataset: uspto-grants-1997_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05633240

Reaction notes

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