HCID 54087854, compound → HCID 54288881, compound

HRID 1781259Notes

Reaction equation

HRID 1781259 reaction equation
[OH:1][C@@H:2]([CH:4]1[CH:7]([C:8]([O:10]CC2C=CC=CC=2)=[O:9])[NH:6][C:5]1=[O:18])[CH3:3]>CO.[Pd]>[OH:1][C@@H:2]([CH:4]1[CH:7]([C:8]([OH:10])=[O:9])[NH:6][C:5]1=[O:18])[CH3:3]

Participants

4

Reactant 1

HCID 54087854HCID 54087854, compound

Product 1

HCID 54288881HCID 54288881, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3(b) 500 mg of the benzyl 3-[(R)-1-hydroxyethyl]-2-oxoazetidine-4-carboxylate (prepared as described in above) were dissolved in 5 ml of methanol, and the mixture was hydrogenated in the presence of 100 mg of a 10% w/w palladium-on-carbon catalyst at room temperature for 2 hours. At the end of this time, the catalyst was removed by filtration. The filtrate was concentrated by evaporation under reduced pressure, to give 310 mg of the title compound as a colorless oil.

Workup

  1. customAt the end of this time, the catalyst was removed by filtration
  2. concentrationThe filtrate was concentrated by evaporation under reduced pressure

Sources & evidence

ORD record
ord-889bb27b57964e04bf32c3b369fdcdbb
Source dataset
uspto-grants-1997_05
Patent number
US05633243

Reaction notes

Loading…