Potassium Hydroxide → HCID 22872995, compound

Participants

Reaction Steps

The procedure is as in Example 4, but starting with 0.6 g of methyl (4R)-3-[3-{2-[4-tert-butoxycarbonyl-2-[(2RS)-5-norbornen-2-yl]-3-thiazolidinyl]-2-oxoethyl}ureido]phenylacetate (mixture of isomers C and D) and 0.074 g of potassium hydroxide. 0.03 g of (4R) -3- [3-{2-[4-tert-butoxycarbonyl-2-[(2RS) -5-norbornen-2-yl]-3-thiazolidinyl]-2-oxoethyl}ureido]-phenylacetic acid (mixture of isomers C and D) is thereby obtained in the form of an amorphous white product.

Provenance & Evidence